There are so many point of origin from the questions who discovered stem cells first, because of there are so many research which has already done surrounding stem cells research in all over the world, we will try to discuss it with the very great respect to all of the scientists from all over the world according to their dedication to stem cells research to find the new methods of curing and reduce people’s suffering and patients illnesses.
The invention of stem cells is basically credited to Alexander A. Maximow. He was a Russian-American doctor, biologist and scientist. He was born on January 22nd, 1874 in Russia. He studied in Germany and America and achieved an M.D. from the Imperial Army Academy in St. Petersburg. He was a histology and embryology professor from 1903 to 1922. He additionally served on the University of Chicago as professor of anatomy from 1922 to 1928.
He proposed the existence of hematopoietic stem cells and described his unitarian principle of hematopoiesis during that event. He was the first individual to use the time period “stem cells” for scientific and medical purposes. Alexander Maximow died in 1928. Later, other physicians and medical researchers such as Joseph Altman, Gopal Das, Andre Gernez, McCulloch and Until discovered numerous traits of stem cells.
Alexander A. Maximow developed the theory that all cells come from the same precursor cell, which he later calls as stem cells.
1908: A Russian histologist, named Alexander Maksimov, is the primary to suggest the term “Stem Cell”. Maksimov proposed the term throughout a congress of the hematologic society in Berlin. He was the primary to hypothesise the existence of haematopoietic stem cells.
1924: Alexander A. Maximow identifies a singular kind of precursor cell throughout the mesenchyme that develops into several types of blood cells. The cells found, have been later revealed to be mesenchymal stem cells.
1960s: Two scientists, Joseph Altman and Gopal Das, present scientific data that indicate adult neurogenesis within the brain, suggesting the existence of neural stem cells. Their findings again then, contradicted the extensively accepted “no new neurons” dogma of Cajal. In consequence their work and findings had been largely ignored by the scientific community.
1963: James Edgar Until, along with Ernest McCulloch, are the primary as an example the existence of self-renewing cells in mouse bone marrow. They had really found the existence of hematopoietic stem cells.
1968: A bone marrow transplant is successfully used (for the first time) between two siblings for the treatment of Extreme mixed immunodeficiency (SCID).
1978: Haematopoietic stem cells are discovered in human twine blood.
1981: Martin Evans together with Matthew Kaufman, manage to extract mice embryonic stem cells from mice blastocysts. In addition they cultured and cultivated them. Throughout the identical year, Gail R. Martin nearly simultaneously illustrated various methods for extracting mouse embryonic stem cells. She is attributed for coining the “embryonic stem cell” term.
1989: Sally Temple, describes the existence of multipotent, self-renewing progenitor and stem cells in the subventricular zone (SVZ) of the mouse brain.
1992: Brent A. Reynolds and Samuel Weiss manage to isolate neural stem cells from the adult striatal tissue, together with the SVZ of grownup mice mind tissue. Concurrently the workforce of Constance Cepko and Evan Y. Snyder remoted multipotent cells from the mouse cerebellum and transfected them with the oncogene v-myc
1997: John E. Dick publishes the primary examine that implies the existence of cancer stem cells.
” 1998: James Thomson, alongside with his crew, becomes the first one to derive human embryonic stem cells. In the same year, John Gearhart (from Johns Hopkins College) extracted germ cells from fetal gonadal tissue before developing pluripotent stem cell traces from them.
2001: Researchers of Superior Cell Expertise turn out to be the primary ones to clone early staged human embryos (on the stage of four to six cells)
2003: Songtao Shi, discovers that the first tooth of children can be utilized as a new supply for extracting grownup stem cells
2004-2006: In 2004 Hwang Woo-Suk announced the creation of several human embryonic stem cell strains from unfertilised human oocytes. It was later shown that his work was fabricated and no human embryonic stem cell lines have been truly produced.
2005: Researchers from UC Irvine’s Reeve-Irvine Research Centre manage to partially restore mobility in paralysed rats, with induced spine harm, by utilizing neural stem cells.
April 2006: Scientists on the College of Illinois at Chicago identify cord blood-derived multipotent stem cells with pluripotent capacities.
August 2006: Shinya Yamanaka becomes the first to derive induced pluripotent stem cells from mice.
October 2006: Scientists at Newcastle University in England turn out to be the primary to differentiate umbilical twine blood stem cells into liver cells
January 2007: A research team led by Anthony Atala discovers a new kind of stem cell, amniotic fluid stem cells (AFS cells). These stem cells are found to be pluripotent in nature.
October 2007: The nobel prize for Physiology or Drugs goes to Mario Capecchi, Martin Evans, and Oliver Smithies for their pioneering work on mouse embryonic stem cells.
November 2007: Shinya Yamanaka once more comes first. This time, for being the primary one to create human induced pluripotent stem cells. James Thomson and his group comes shut second, for a similar achievement.
January 2008: Advanced Cell Expertise researcher Robert Lanza proclaims the primary production of human embryonic stem cells that didn’t require the destruction of an embryo.
March 2008: The primary stem cell associated study of succesfully regenerated human knee cartilage is published. The examine entails using autologous mesenchymal grownup stem cells.
October 2008: A workforce from Germany led by Sabine Conrad creates human pluripotent stem cells from spermatogonial cells of adult testis. In the same month scientists created induced pluripotent stem cells from a single human hair
November 2008: Paolo Macchiarini transplants the primary human organ, fully grown from stem cells. It was a trachea which was transplanted on a Colombian female who had her personal collapsed because of tuberculosis.
eleven October 2010: The first human scientific trial involving embryonic stem cells commences. The trial was later cancelled, supposedly for monetary reasons. As of in the present day no info concerning the few handled sufferers has been released. During the trial paraplegic sufferers with spinal cord injuries had been imagined to be handled using human embryonic stem cells. Solely a handful obtained the treatment prior to the trial’s cancellation.
June 2011: A group of Israeli scientists led byInbar Friedrich Ben-Nun produce stem cells from an endangered species. Their work has the potential to in the future save many various species which might be at risk of extinction.
December 2012: Advance Cell Know-how announces human stem cell clinical trial
28 July 2013: The primary stem cell hamburger is cooked and consumed