How do stem cells work in the cornea? It’s a very interesting question isn’t it …? After you have already finished to read this article, you will understand the process of how do stem cells work in the cornea, I will try to write each part of the word as simple as I can so that all of the people who read this article could understand the meaning of it and could imagine how it works, hope so…:)
The Cornea is a part of our eyes, the eye is the organ which is responsible for our ability to see the world all around us. It is able to detect light from the surrounding environment and transfer information about what it has detected to the brain. The eye is a very complex organ made up of multiple, specialized components, the components or tissues are made up of many types of cells, each with a specific job to do to enable the tissues to perform specialized roles.
The scientists and researcher using mouse models they demonstrate that everyday wear and tear on the cornea is repaired from stem cells residing in the corneal epithelium, and that more serious repair jobs require the involvement of other stem cells that migrate from the limbus, a region between the cornea and the conjunctiva, the white part of the eye.
All of us know that the integrity of the cornea, the transparent outer layer of the eye, is very critical for vision. Thousands even millions of people around the world suffer from partial or complete blindness when their corneas lose transparency. Treatment options involve corneal transplants and, more recently, stem cell therapy. The surface of the cornea is naturally in a state of constant renewal; its upper layer, or epithelium, is completely turned over once every 7-14 days. Because slow-cycling stem cells have been found in the mouse limbus, researchers have assumed that these stem cells are the ones responsible for corneal renewal.
To explain this distribution of stem cells and the different roles played by stem cells in different zones of the eye, the researchers propose that the expanding epithelia of the cornea and the conjunctiva act like tectonic plates, squeezing the limbus between them into a kind of equilibrium zone. Due to the constant expansion, stem cells accumulate in this zone. In the event of a rupture in the equilibrium, such as a large corneal injury, these limbal stem cells migrate into the cornea and conjunctiva and differentiate into the appropriate cell type to make repairs, it’s very amazing isn’t it…?
The limbus is already recognized as a source of cells for corneal stem cell therapy in humans, and this new research indicates that the cornea itself can also be explored as a potential source of these cells. And because cancer has been associated with the presence of adult stem cells, the model also helps explain why transitional zones like the limbus, where stem cells accumulate, are sites where cancer tends to occur more frequently, hope this little article could make us understand a little bit of the process on how do stem cells Cells Work In The Cornea.