There’s been a lot of fascinating research and study according to Amyotrophic Lateral Sclerosis (ALS) stem cell research trials, first of all we will discuss about Amyotrophic Lateral Sclerosis itself, what kind of disease is that ?
Amyotrophic Lateral Sclerosis (ALS) also known as Lou Gehrig’s disease, is a condition of progressive degeneration of motor neurons in the cortex, brainstem and spinal cord. The Sign and symptoms of the people with ALS may experience weakness in their limbs followed by a rapid and progressive paralysis that leads to respiratory insufficiency, respiratory failure even death within an average of 3 – 5 years from the onset of the disease. ALS causes is largely unknown and until now there is currently no effective therapy.
Amyotrophic Lateral Sclerosis (ALS) is a complex disease, there’s several factors contribute to the difficulty in finding effective therapies for ALS. Almost 90 % of cases are sporadic, which means a comnination of genetic mutations or presumed environmental is the causes. There’s only 10 % of ALS cases are caused by inherited forms of known genes. This means that the therapy would only be effective on a certain subset of patients. Without understanding what causes of ALS it is very difficult to threat the patients.
However, in recent years stem cell transplantation has emerged as a potential new therapy for patients with ALS. It’s more rationale for using stem cells as support cells for dying motor neurons as they are already connected to the muscle, besides of motor neuron replacement which remains a focus of some studies trying to treat ALS with stem cells. This could be through reducing inflammation, releasing growth factors and other related unknown mechanism.
Poor understanding of what causes ALS and whether stem cells may ameliorate wymptoms, there should e a push to determine cell safety in pre-clinical models and then a quick translation to the clinic ehre patient trieals will show if there is any efficacy.
Based on the research that has already done by several researcher some stem cell approaches in animal models provide a strong rationale and evidence to suggest that stem cell therapy has great potential to delay the degeneration of motor neuron and potentially enhance function in ALS patients. Even though not all pre clinical animal models support this hypothesis, it should be considered that these models are subject to many limitations such that final proof may require confirmation in human affected by the disease.
Based on a lot of research and journal, in some country right now has already using stem cells therapy for ALS patients, and the result is very surprising which is stem cells can reduce the patients suffer because of their disease and raise the quality of life of the patients with ALS. Here you can find Pros and Cons of Stem Cell Research List..
I only make a resume from a lot of article, research and journal from the ALS stem cell research trials, because if we discuss it one by one it will need a lot of your time to read it, and will take more than a year for you to read this article .. 😉
That’s all from me today, wish I could share something meaningfull for all of you,
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